If your recipients are genuinely in the US, GDPR, an EU regulation protecting people in the EU, doesn't govern those sends. US B2B cold email runs under CAN-SPAM: honest headers, identification, physical address, working opt-out.
The practical caution: lists leak across borders. A 'US company' contact may sit in a Dublin office; scraped lists especially mix geographies. If EU residents may plausibly be on the list, either scrub by geography or meet the higher bar (legitimate-interest analysis, easy objection) for everyone.
Our lawyer-line applies: this is the widely-published shape of the rules, not legal advice. A volume outreach program touching international lists is worth one billed hour of real counsel.